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Lyc-O-Mato, Natural Lycopene Complex

by Lyle Hurd, editor

Heart disease, breast cancer, ovarian cancer, skin cancer, endometrial cancer and osteoporosis—what do they have in common? They are all caused by oxidative stress and they can all be prevented by tomatoes. The tomato may very well be one of nature most perfect foods, containing phytonutrients that help prevent oxidative damage, which serves to protect against the leading health problems of women.

Tomatoes, as well as natural tomato extracts like Lyc-O-Mato? the subject of well-publicized research, contain a variety of health benefiting phytonutrients: lycopene and beta carotene, as well as antioxidant tocopherols (vitamin E), phytosterols and the less well-known carotenoids, phytoene and phytofluene. Studies have shown that these natural substances decrease the proliferation of human cancer cells and support cardiovascular health. Recent data suggest that they may even be important in maintaining bone health.

Oxidative stress occurs when our cells are bombarded with free radicals, by the sun and other environmental factors. When free radicals occur in excess, they damage the structure and function of our cells. The resulting oxidative stress leads to degenerative conditions such as cancer and cardiovascular disease. A diet rich in fruits and vegetables can help offset this damage because of the antioxidant carotenoids which act as free radical quenchers.

The combination of lycopene, phytoene and phytofluene present in tomatoes has specifically been shown to decrease cancer risk. The human body does not produce lycopene on it own; health conscious individuals should be eating a lycopene and phytonutrient- rich diet or taking an all-natural tomato extract supplement.

Dr. Edward Giovannucci, from Harvard Medical School, recently reviewed 72 epidemiological studies and found that 52 of those studies pointed to the role of tomatoes and tomato products in reducing the risk of a variety of cancers. This is especially important news for women because lycopene, combined with phytoene and phytofluene, has been shown to interfere with breast and endometrial cancer cell growth, help prevent tumors and reduce the progression of new ones and is associated with a reduced risk of ovarian cancer. The beneficial effects of tomatoes and natural tomato complex become even more relevant for women when the topic is breast cancer, the leading cancer in women.

Lyc-O-Mato may be effective in preventing prostate cancer.
In a six-year study of 48,000 male health professionals, Dr. Giovannucci and colleagues at Harvard Medical School found that consuming tomatoes, tomato sauce or pizza more than twice a week, as opposed to never, was associated with a reduced risk of prostate cancer of 21 to 34 percent, depending on the food.

As exciting as its cancer prevention potential is the evidence that shows that lycopene may help fight existing cancer. A paper published in Cancer Epidemiology, Biomarkers and Prevention by Omer Kucuk, M.D., professor of medicine and oncology, and his colleagues at the Karmanos Cancer Institute in Detroit, Michigan, evaluated the effect encapsulated Lyc-O-Mato had on patients with existing prostate cancer. In this study Dr. Kucuk and colleagues followed 30 men with localized prostate cancer who were scheduled to undergo surgical removal of the prostate. For three weeks prior to surgery the study participants were randomly assigned to receive either 250 milligrams Lyc-O-Mato from LycoRed Natural Products, Beer-Sheva, Israel (which contains 15 milligram of lycopene) twice daily or no intervention. Following removal of the prostate, the glands were analyzed to determine whether there were any differences between the two study groups. The investigators found that the treated group had smaller tumors, which were more likely to be confined to the prostate. Levels of serum PSA were found to decline in the patients who received Lyc-O-Mato tomato extract. In addition, the tumors in patients who consumed this natural lycopene showed signs of regression and decreased malignancy.

More than 50 million Americans suffering from hypertension are seeking advice from their doctors to find the best way to lower their blood pressure. Often referred to as a ilent killer,?hypertension contributes to more than 75 percent of all strokes and heart attacks, affecting more than half of all Americans over age 65. Many are being advised to make major lifestyle changes, including eating right and exercising. Others are taking expensive blood pressure-lowering medication that can sometimes have serious side effects.

Research published in abstract form in the May 2002 issue of the American Journal of Hypertension could provide a new treatment alternative for hypertensive patients unwilling to make lifestyle changes or take blood-pressure lowering medications. In a single-blind, placebo-controlled crossover trial, Esther Paran, M.D., the study principal investigator, evaluated the effect of Lyc-O-Mato, a standardized natural tomato extract rich in lycopene, on 35 male hypertensive patients.

Paran, who is head of the Hypertension Unit at Soroka University Hospital, Faculty of Health Sciences, Ben-Gurion University of the Negev in Ber Sheva, Israel, studied mild hypertensive patients between the ages of 45 and 60 years old. The patients were administered a daily dose of identical placebos for the first four weeks of the study followed by a 250 mg daily dose of Lyc-O-Mato, which contains 15 mg of lycopene, for the final eight weeks of the study. Preliminary results of the study indicated a significant reduction in systolic blood pressure in treated patients.

his research is the first of its kind to provide documented evidence that a natural tomato extract can manage blood pressure in mild hypertensive patients,?Dr. Paran said. his is fantastic news for those who have had a difficult time controlling mild to moderate hypertension through lifestyle changes alone.?

The study found systolic blood pressure was lowered from 144 to 135, an average of 9 mm Hg reduction. Diastolic blood pressure was lowered an average of 4.5 grams mm Hg. Beneficial effects on blood lipids, lipoproteins and oxidative stress markers were also noted in the study.

he level to which blood pressure was lowered as a result of Lyc-O-Mato was comparable to the level at which blood pressure is lowered through drug intervention,? Dr. Paran stated.

Lyc-O-Mato is available in softgel form in dietary supplements as well as in tablets and capsules. It is also finding its way into functional foods. Most significant epidemiological studies, including those cited in this article, utilized dosages of 250 mg of Lyc-OMato per day, which contains 15 mg of lycopene along with other phytonutrients. Consumers should look for labels indicating ?5 mg of lycopene from Lyc-O-Mato or a standardized natural tomato extract.?
 
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