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Multiple Allergic Response Syndrome (MARS) PDF Print E-mail

The invisible illnesses known as fibromyalgia, chronic fatigue, myofascial pain syndrome, arthritis and digestive disorders

Non-drug solutions to heal and repair damage from prescription drugs, years of health-depleting dietary choices and chemically-induced immune system disorders.
by Gloria Gilbère, N.D., DAHom., Ph.D.


“Disease enters and leaves man as through a door,” wrote French philosopher Georges Canguilhem more than a half century ago, illustrating the notion that disease is a distinct “thing” existing apart from the human body. Sadly, this view still prevails towards the more than 26 million people afflicted with the invisible disorders stemming from varied chemical exposures.

Our ancestors attributed their maladies of unknown origins to evil spirits; today we speak confidently about disease-generating microorganisms. With the invisible illnesses an opinion not so different from that of our ancestors, exists among some physicians, health practitioners, families, insurance companies and employers. The opinion is that those suffering symptoms of multiple chemical sensitivity (MCSS), fibromyalgia, arthritis, chronic fatigue and myofascial pain syndrome must have some hidden demon that brings on these “invisible” disorders. This opinion arises from a society that will not recognize an illness without double-blind studies and a scientific name for the illness. If you, the victim, appear “normal,” then it must be psychological, not physiological.

Fortunately, a different opinion is finally emerging—that disease is not a separate entity but a changed state of the organism, a disturbance of the natural equilibrium or harmony of the body systems caused by build up of toxic residue. What is equally important to note is the insight of the past decade declaring that all diseases are both genetic and environmental. Is it any wonder that attacks on our immune system occur as we North Americans litter, smoke, drive more cars, pour on the fragrances, rely on bug bombs, use more than our share of the world’s resources, rely on prescription medications for symptom care instead of finding the cause and create mountains of smelling, toxic garbage? We have supported a disposable and unnatural society—Styrofoam, plastic and food that stays fresh for weeks and even years. This generation of chemicals was synthesized after World War II and includes pesticides, synthetic fragrances, cleaning products, food preservatives and coloring, detergents and petrochemical based products, very toxic to humans, animals and our ecosystem.

What are MARS and chemically induced immune system disorders?
MARS is an adverse reaction to toxic chemicals in the air, food or water at concentrations generally considered harmless to the healthy population. People with MARS manifest acute sensitivity to natural gas fumes, gasoline, car exhaust, dyes and chemicals in fabrics, synthetic clothing and fabrics, synthetic or chemically-treated carpets, cleaning materials, phenolated compounds, perfumes and smoke from cigarettes or other sources, to mention a few.

However, when a healthy body is repeatedly exposed to toxic chemicals, the body develops a decreased tolerance. The immune system becomes overburdened, leading to autoimmune disorders and subsequent multiple allergic responses. When a person with a compromised immune system is exposed to toxic chemicals, the sick get sicker and may even die from the allergic reaction or the resulting side effects from drug therapies given to deal with the symptoms of the reaction.

According to studies conducted by the California Department of Health in 1995 and published in ”Multiple Chemical Sensitivity Research Reports,“ 17–34 percent of Americans report symptoms of chemical sensitivity. The studies also show that two-thirds of patients with MARShave been diagnosed with chronic fatigue and fibromyalgia. Furthermore, it is estimated that 50 percent of office visits in general practice today are related to complaints of food, prescription drug and environmental responses.

Allergic reactions are as diverse as the persons themselves, however, more and more people are developing severe allergies as a result of living in a toxic world. These allergies are known as chemically-induced immune system disorders and are a fast spreading phenomenon associated with chemical hypersensitivity. Of this number up to 80 percent also have chronic fatigue syndrome; 65 percent have fibromyalgia, and over 85 percent have digestive and immune disorders.

Because chemicals are everywhere, it’s impossible to completely escape exposure. These environmental allergens are life changing, and often life destroying for the person afflicted and those around them. The resulting allergic reactions affect not only the way our body functions but the physical, sociological, and emotional quality of life as well.

Most individuals acquiring MARS and the associated syndromes are looked upon as chronic complainers. The few physicians and health care practitioners specializing in environmental medicine deal with the patient’s symptom care, neutralization therapy and environmental modifications in their home and office. What is grossly overlooked is the importance of detoxifying the liver, intestines (large and small), the lymphatic system and soft connective tissue of toxic substances. Only when detoxification occurs can there be lasting reversal of symptoms and a return to natural equilibrium of the body systems.

Defining internal toxicity?
Attention has been focused on the small intestine and the connection to MARS, fibromyalgia and chronic fatigue, especially as it relates to a disorder called leaky gut syndrome, clinically known as intestinal permeability. This is where the villi (brush borders) of the small intestine are weakened and allow toxic material and food particles to permeate and enter the bloodstream. What is not often discussed is the leaking of toxic matter from the walls of the large intestine. The large intestine (colon) is intimately connected through an elaborate system of veins and venules into the liver, through a portal venous system and the lymphatic system through the cisterna chili. The more appropriate name for leaky gut syndrome would be autointoxication.

This is the process by which the body literally poisons itself by maintaining a cesspool of decaying toxic matter in the colon. The toxins released by the decay process circulate into the bloodstream and travel to all parts of the body. Every cell is affected and because the toxins weaken the entire system, autointoxication and many forms of “incurable diseases” get their start in the colon. Still another source of intestinal poisons is putrefaction of the portion of the protein from food that fails to undergo absorption, caused by an enzyme deficiency.

Intestinal poisoning not manifesting immediate visible effects appear in disorders such as MARS, fibromyalgia, chronic fatigue, lupus, peripheral neuritis and arthritis, to mention a few. Eventually the chemicals produced by putrefaction are so poisonous they irritate the delicate lining of the large intestine and destroy the protective barrier keeping out the invading toxins. Damage from the chemical toxins is so destructive, the colon walls become leaky and allow penetration through the damaged barrier into the lymphatic and circulatory systems, especially through the hepatic portal vein.

The role of the lymphatic system in MARS
The lymph nodes act as a filtering station, detecting foreign and potentially harmful substance in the lymph fluid. The lymph nodes act like spongy filter sacks and are part of the lymph system. Lymph fluid in an adult equals one to two quarts and accounts for one percent to three percent of body weight. This is basically the body’s secondary circulation system and thus toxic substances are circulated throughout the system directly through the lymph ducts and nodes connected to the small and large intestines. Lymph vessels are located throughout the body and are more numerous than blood vessels.

The lymphatic system, four times larger than the blood system, provides the means for each individual cell to get rid of waste. Lymph handles only cell wastes; however, when the blood is also dumping waste toxins from the intestinal tract into the lymph system via the liver, the lymph becomes overworked and its filtering/neutralizing function is decreased. This buildup of toxic lymph fluid is what contributes to the inflammation and pain in soft and connective disorders as in fibromyalgia and myofascial pain syndrome.

Synthetic and toxic substances are all around us, specifically:
  • Clothing
  • Mold
  • Medications
  • Bedding/mattresses
  • Pesticides/herbicides
  • Air fresheners
  • Petrochemicals
  • Fragrances
  • Detergents/fabric softeners
  • Personal care products
  • Building materials/particleboard
  • Water systems
  • Fertilizers/garden products
  • Food preservatives/dyes
  • Stains/paints/varnishes
  • Plastics
  • Carpet/padding
  • Furniture/laminates
  • Glues/adhesives
  • Wallpaper
Non-steroidal anti-inflammatory drugs (NSAIDs)
Helpful Drugs: Serious side effects NSAIDs are distinguished from those that contain corticosteroids. They are a group of drugs most frequently used to reduce swelling, inflammation and pain. The drugs work by inhibiting the enzyme cyclooxygenase. This enzyme is responsible for the production of prostaglandins, a hormone-like substance involved in the development of pain and inflammation. Especially in people with MARS, inflammatory and digestive disorders, these drugs can have serious side effects.

In the U.S. alone, 75 million prescriptions for NSAIDs are written annually. Yearly an estimated 7,600 people die from the effects, including gastrointestinal bleeding and perforation; that’s one death for every 9,210 prescriptions. Another 76,000 are hospitalized; that’s one hospitalization for every 921 prescriptions.

According to the medical journal Lancet, chronic use of NSAIDs, especially in high doses, increases the permeability or leaking of the colon. This leaking actually creates allergies and contributes to arthritic and inflammatory symptoms, the very reason most people take an NSAID in the first place. Many cases of developed MARS, including my own, are linked to the consumption of NSAIDs and over-use of antibiotics. There are “safe” options for pain and inflammation found in systemic oral enzymes. (Refer to my books for details and recommendations.)

It is now believed that most pain and inflammation associated with MARS, and the inflammatory disorders, occurs from the buildup of toxins stored in the soft and connective tissue. Those of us who have experienced the invisible horror of fibromyalgia describe the pain as “muscle spasms that feel like the nerve endings are on fire”—while there can also be coldness in the extremities from the resulting swelling and sluggish lymphatic flow.

Multiple Allergic Response Syndrome (MARS), also called Environmental Illness (EI), is a syndrome because it stems from a variety of causes. It is a medical condition developed by individuals exposed to chemicals in their environment that affects the neurological, immune, respiratory, skin, gastrointestinal and musculoskeletal systems. Environmental medicine, also called clinical ecology, was first developed by Dr. Theron Randolph in the 1940s, when he observed, early in his medical career, that food allergies and sensitivities to environmental chemicals were a major contributing factor in a wide range of allergies and diseases, including arthritis. He then discovered, of those treated by standard medical diagnostic techniques and confirmed arthritics, more than half were helped by making dietary and environmental modifications along with detoxification.

Low levels of toxins may have been previously tolerated and suddenly the body loses the ability to neutralize the chemicals and an allergic reaction occurs. The onset can be triggered from a single major exposure (as in pesticide poisoning); long-term exposure to low levels (food preservatives and additives, sick buildings, mold, off-gassing from computers, copiers, cleaning products, carpets, building supplies); side effects of prescription drugs (especially medications for pain and inflammation); serious illness or trauma. This is truly an example of our “toxic cup runneth over.” When our bodies (specifically the liver) can’t neutralize toxins as quickly as they’re being introduced, that one last exposure is what does us in.

The chemicals synthesized after World War II (pesticides, fragrances, synthetic fabrics, cleaning products, detergents, etc.) are mostly “petrochemicals” (petroleum based) and are extremely toxic to humans. There have been virtually no studies done on the majority of these chemicals to determine consequences on humans—the industry just places the chemicals in the environment with the assumption that they are “safe, until proven toxic,” instead of insuring their safety before allowing them to be used.

According to a study by the National Academy of Sciences, 95 percent of chemicals used in fragrances are synthetic compounds derived from petroleum. Yes, the same ingredient as GASOLINE. The danger lies in that the perfume industry in NOT REGULATED—they can include any number of chemicals in a fragrance without revealing what those chemicals are—or how they affect humans. We humans are all participating in a giant “lab experiment,” against our knowledge and our will, and it’s making millions of us VERY sick.

Symptoms of MARS
(limited list)
  • Recurring headaches/migraines
  • Asthma or chronic bronchial disorders
  • Increased sensitivity to odors
  • Dizziness/lightheadedness
  • Food/environmental allergies
  • Aching joints/muscles
  • Numbness/tingling
  • Non-injury related inflammation
  • Blurred vision/light sensitivity
  • Intestinal/colon disorders
  • Unexplained rashes
  • Chronic insomnia
  • Impaired mental clarity
  • Chronically sore eyes, ears, nose and throat
  • Restricted swallowing
  • Anaphylaxis (in acute cases)
Formaldehyde is another toxic chemical that causes many of the symptoms of MARS, including dizziness, chronic headaches, sinus infections, lightheadedness, memory impairment, attention disorders and allergies. Many of the ingredients in construction, especially mobile and modular homes, are made with particleboard, glues, plastics and toxic finishes—all of which can outgas toxic substances and formaldehyde. Repeated exposure weakens the immune system, making one more vulnerable to other toxic chemicals. Formaldehyde is in many products including some cosmetics, baby shampoo and baby lotion. Look for “Quaternium-15” on the label—that’s formaldehyde in disguise. It’s also in clothing and bedding—if they’re permanent press (polyester combination), crease resistant or a synthetic composition. Years of laundering does not remove the formaldehyde—it’s even in some of the food we eat. Yes, formaldehyde is the stuff they embalm people with; at this rate, we won’t need embalming when we die.

In the early stages of MARS, repeated exposure to the substance or substances that caused the initial health effects provokes a reaction. After a time, it takes less and less exposure to the related chemicals to cause symptoms. As the body systems break down, an ever increasing number of chemicals, including some unrelated to the initial exposure, are found to trigger a reaction.

Once an individual becomes sensitized, he/she must avoid a wide array of chemicals in everyday life such as fragrances, detergents, fabric softeners, auto exhaust fumes, fuels (gas/propane), smoke, insecticides, weed killers, volatile organic compounds found in paints, solvents and new building materials and furnishings. Many people also become hypersensitive to molds, aromatic plants and wood such as cedar.

Those of us who are becoming chronically ill from these chemicals are similar to the “canaries in the coal mine.” Coal miners would take a canary into the mines with them to warn when the air became toxic; if the canary stopped singing or died, it was time to get out! We “human canaries” are here to warn the rest of you that, unless you become informed and start making changes to avoid as many toxic chemicals as possible, you too may become very ill, or even die, from the consequences. Today we live in a world that offers us safe alternative products and therapies of every kind. Be an informed consumer—with knowledge you can reverse and prevent these disorders. I did and so have the thousands of clients who follow my detoxifying and lifestyle protocol, naturally.

Gloria Gilbère is a doctor of naturopathy and natural health, member of the American Academy of Environmental Medicine and the American Naturopathic Medical Association. She is an environmental health consultant, natural health journalist and researcher. She is author of I Was Poisoned By My Body (Lucky Press, 2001), Invisible Illnesses (Freedom Press, 2002) and her latest book, Nature’s Prescription Milk (Freedom Press, 2003).

Visit her Web site at www.drgloriagilbere.com Listen to her radio show on www.healthylife.net
 
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