SOD/Gliadin Defense Against Disease and Aging
by Carl Germano, R.D., CNS, CDN
Importance of SOD
The population of the world is rapidly aging.
Life expectancy in most developing nations
is now almost 80 years old. Currently a great
deal of annual healthcare expenditures are
attributed to older people. These individuals
typically suffer from a number of pre-disease
conditions and chronic diseases, such as;
arthritis, hypertension, cardiovascular disease,
cancer, diabetes, immune deficiency,
memory and cognitive impairment, depression,
etc. These chronic conditions are constant
and lifelong ailments that the senior
population must contend with on a daily
basis. Today one dietary ingredient stands
out to be the most important defense against
aging and disease by virtue of the fact that
each and every cell manufactures and
depends upon its existence to survive—
Superoxide Dismutase/Gliadin (GliSODin?.
Superoxide Dismutase—The Master Cellular Defense Enzyme
Superoxide dismutase (SOD) is truly the
cells?master defense mechanism to quench
the damaging effects of free radicals. SOD
primary function is to convert the free radical
superoxide into hydrogen peroxide, a
less-harmful free radical. Among the free
radicals, superoxide is the most powerful and
dangerous. Additionally, superoxide, along
with nitric oxide, leads to the generation of
peroxynitrite, which is principally responsible
for the death of the cell. When superoxide
is allowed to run rampant in the body,
cellular impairment and disease process
accelerates. Essentially, SOD can help intervene,
delay and in some cases, prevent the
disease process. Lastly, SOD plays other
important roles in the body via its ability to
affect the immune system, inflammatory
cytokines and other noxious agents that are
implicated in ill health.
GliSODin Discovery and Importance: The
First Orally Effective Vegetarian Form of
SOD
After decades of research, a team of French
scientists at Isocell finally developed a
unique oral delivery system that combines
gliadin (a wheat protein extract) with a 100
percent vegetarian form of SOD, which
comes from cantaloupe melon. In scientific
studies, these researchers demonstrated that
the gliadin polymer protected SOD from
stomach acid and intestinal digestive
enzymes and delivered SOD intact to the
cells of the body, where it could be effectively
used in a variety of antioxidant
defense and immune support mechanisms.
Furthermore, these studies showed that
blood levels of SOD were markedly
increased after ingesting GliSODin, which
indicated that the antioxidant enzyme,
SOD, was effectively absorbed and utilized
from the intestines. In additional studies,
GliSODin was shown to increase the body
own production of SOD and other important
defense enzymes, such as catalase and
glutathione peroxidase.
The effects of GliSODin are directly
proportional to the amount absorbed;
that is, the more consumed, the greater the effect and this effect has been sustained up to 12 hours after ingestion. Many in vitro animal and human studies demonstrate the importance and effectiveness of
GliSODin as follows:
In vitro studies demonstrated that:
Gliadin promotes the delivery of SOD into
immune and gastrointestinal cells.
GliSODin reduces levels of superoxide
Animal studies demonstrated that:
GliSODin increases circulating SOD levels
and has long-lasting effects.
GliSODin raises liver defenses and reduces
oxidative stress.
GliSODin was shown to be effective in a
variety of animal disease models, including:
- Liver fibrosis
- Drugs and xenobiotics liver toxicity
- Neuroprotection
- Protection against allergic airway inflammation
- Anti-inflammatory
- Stimulation of antitumoral defenses.
Human clinical studies demonstrated that:
Two-week GliSODin treatment helped modulate
circulating SOD activity in healthy
humans.
Two-week GliSODin treatment prevented
circulating lactate accumulation and resulted
in significant decreases in lactate levels in
healthy human volunteers/cyclists
after intense exercise.
A significant effect
demonstrating an
effective sports
application for
GliSODin.
Two-week GliSODin
treatment in healthy
human volunteers
exposed to hyperbaric-induced oxidative
stress showed a significant protective effect
on DNA damage compared to control
groups.
In many chronic diseases, levels of SOD
are typically depressedften weakening
defenses and exacerbating the condition. A
study in HIV-infected subjects demonstrated
that only GliSODin was able to increase SOD
levels and other defense enzymes typically
depleted as well.
In addition, over the past 18 months a
formula containing GliSODin has been consumed
by hundreds of individuals living
with HIV/AIDS (PWAs) as an adjunct to their
medical care. The results have been remarkable
and with no adverse reactions having
been reported. At this juncture the product
marketed by Millennium Biotechnologies,
Inc. has been approved by Medicare and
Medicaid in several states.
GliSODin can be found in health food
stores and plays an important adjunct to any
nutritional protocol either as a stand-alone
or as part of a unique formulation.
Carl Germano, R.D., CNS, LDN is a registered,
certified and licensed nutritionist and
has been appointed to the NY State Board of
Nutrition and Dietetics. He holds a master
degree in clinical nutrition from New York
University and has over 22 years experience
using innovative, complementary nutritional
therapies in private practice.
For those interested in learning more about
SOD/Gliadin, his book Sod/Gliadin: The
Ultimate Defense Against Disease and Aging (Twin
Streams a Kensington Publication, 2001) provides
a more in-depth perspective on the important
relationships between SOD and disease, as
well as some of the clinical applications of SOD
that have been reported in the literature. For
more information, including where to find
GilSODin e-mail PL Thomas & Co., Inc. at
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