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Nexrutine: A Breakthrough in Natural Pain Management |
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Nexrutine:
A Breakthrough in Natural Pain Management
by James B. LaValle, R.Ph., N.M.D., C.C.N.
If you live long enough, chances are
that by age 50 you are going to have
some arthritic condition. In fact, 80
percent of people over the age of 50
suffer from arthritis. Plus more
people are living active lifestyles and
sometimes the pain and strain from
exercise can make recovery difficult.
Traditionally people turn to a vast number of
over-the-counter (OTC) solutions such as
aspirin, ibuprofen and acetaminophen.
Many people today are looking for natural
options that are safer, offer less long-term
risk and provide solutions to common pain,
inflammation and arthritis.
Over the last few years there has been a
great deal of research in the herbal and
nutraceutical arena in these areas. One such
example of the emerging science in natural
medicine is Nexrutine®.
Nexrutine is an exciting new dietary
supplement that has potent anti-inflammatory
action. A rapidly-acting ingredient,
Nexrutine alleviates the pain associated with
arthritis as well as the joint and muscle soreness
associated with over-exertion or physical
activity. Significantly, test subjects report
that Nexrutine not only eases general aches
and pains but also helps make everyday
activity more comfortable.
Nexrutine is derived from the
Phellodendron tree, a member of the
Rutaceae plant family. This family of plants
has played a significant role in Chinese medicine
and teas made from the Phellodendron
tree itself have been used for centuries to
treat inflammation, abdominal pain and
gastrointestinal discomforts.
Considering the historical use of
Nexrutine’s natural source, it should come as
no surprise that the supplement is safe,
gentle on the stomach and free of side effects.
Some studies have even reported that certain
compounds in Nexrutine actually protect
the gastrointestinal tract against ulceration.
A large number of Americans will be welcoming
this new remedy to their medicine
cabinets. Nexrutine may provide significant
benefits to those who have experienced the
unwanted and sometimes severe side effects
produced by popular prescription and OTC
pain medicines. It will work for those who
simply seek safe, natural pain relief.
Nexrutine as Cox-2 Inhibitor
The lack of side effects is but one advantage
Nexrutine has over other painkillers like
ibuprofen, naproxen and other nonsteroidal
anti-inflammatory drugs (NSAIDs).
Nexrutine’s unique mechanism of action is
an even more compelling attribute. A comparison
with other anti-inflammatory drugs
serves as a good illustration. First, Nexrutine
inhibits the Cox-2 enzyme, a chemical in the
body that causes inflammation. Unlike other
Cox-2 inhibitors, Nexrutine does not act
directly on the enzyme itself. Instead,
Nexrutine’s true strength resides in its ability
to inhibit the actual production of the
enzyme that leads to inflammation so it shuts
off the problem at the source.
Another unique quality of Nexrutine is
that it selectively inhibits the Cox-2 enzyme.
This means that it does not interfere with
another related enzyme in the body, the
Cox-1 enzyme. This “good” Cox enzyme is
involved in maintaining the lining of the
stomach and also promotes kidney function.
Nexrutine leaves the Cox-1 alone to do its
work but the same cannot be said of other
NSAIDs. Many such OTC painkillers block
both Cox enzymes and overuse of these medicines
can prove dangerous. Indeed drugs
that block the good Cox-1 enzyme have been associated with kidney and liver damage and
over 100,000 deaths a year.
 Selective Cox-2 inhibitors are now some
of the most prescribed pharmaceutical drugs
on the market. Recent reports show that
Celebrex™, a proprietary Cox-2 drug, has
surpassed the anti-impotence medication
Viagra™ as the fastest-selling new prescription
drug in history. According to IMS
Health, Celebrex sold 6.86 million prescriptions
during its first six months on the
market, compared with about 5.3 million for
the anti-impotence drug Viagra. The
amazing number of prescriptions for Cox-2
inhibiting drugs, coupled with the fact that
Nexrutine is the first all-natural selective
Cox-2 inhibitor, suggests that Nexrutine has
the potential to become the single major
selective Cox-2 pain reliever available
without a prescription.
It should be noted that all NSAIDs and
Cox-2 drugs can reduce renal function.
Patients on these drugs are at risk for edema
and increased blood pressure. Therefore even
though Nexrutine is gentle and comes from a
plant with a long history of safety, it is a Cox-
2 inhibitor and should be used with caution
and under a physician’s guidance in patients
who have impaired renal function, hypertension
or heart failure.
Other Potential Benefits of Nexrutine
As a Cox-2 inhibitor Nexrutine joins some
exciting news that has recently surfaced
about other uses for these drugs. Because the
pro-inflammatory Cox-2 enzyme is also produced
in human colon cancer cells, Cox-2
inhibiting compounds like Nexrutine could
provide a promising role in an overall cancer
prevention plan. Furthermore, the risk of
developing Alzheimer’s disease, which is
thought to involve an inflammatory component,
may also be reduced by use of NSAIDs.
Lastly, the Phellodendron tree from which
Nexrutine is derived has been shown to have
an effect on the central nervous system and
the potential to help control mild anxiety. For
further information regarding Nexrutine
please visit www.nexrutine.com or call
1-866-nix-pain. TH
James B. LaValle, R.Ph., N.M.D., C.C.N. is the author of The Cox-2 Connection: Breakthrough Treatment of Arthritis, Alzheimer’s and Cancer. Published by Healing Arts Press, Rochester Vermont. He is a faculty member at the British Institute of Homeopathy and the University of Cincinnati College of Pharmacy. Nexrutine is the first all-natural selective Cox-2 inhibitor . . .
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